My current research interests are aimed at understanding the molecular and genetic determinants of neuronal development and nervous system organization currently combining both experimental and in silico strategies.
I investigate molecular mechanisms governing various aspects of nervous system development, function and complexity. From the cellular level, including axon growth and the size and complexity of dendrites in the developing peripheral and central nervous system, to the large scale detection of transcriptional determinants of complex nervous system-related phenotypes.
More recently, I have started developing alternative strategies, combining a range of comparative and functional genomic approaches, aimed at uncovering and identifying genomic and molecular determinants of neuronal survival during early development as well as brain and behavioural complexity across mammalian lineages. Along these lines, using next generation transcriptional profiling, I am currently conducting a whole transcriptome data mining for detection of wider gene networks involved in post-mitotic cell maintenance in a mouse model of accelerated brain ageing. Using a range of gene co-expression network approaches we are also investigating developmental and transcriptional changes associated with complex behaviours in mammals.
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The system we work with: The questions we ask:
The questions we ask: